"An excellent derivative for Fmoc SPPS of Arg-containing peptides. Coupling of this derivative can be effected using standard activation methods, such as PyBOP® or TBTU, although longer reaction times may be necessary due to the bulkiness of the side-chain protection. Fmoc-Arg(Boc)2-OH is an intermediate used in membrane enhanced peptide synthesis."







Fmoc-Arg(Pbf)-OH is the standard form for the introduction of Arg in the Fmoc strategy of solid phase peptide synthesis (SPPS). The side-chain protecting group Pbf is fantastic for the guanidinium group in arginine and can be easily removed with TFA.