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Fmoc-Glu(OtBu)-OH is the standard Fmoc-protected derivatives of Glu used in peptide synthesis. The t-butyl ester of the side chain is removed in the same conditions used to cleave peptides from Wang resin or Rink amide resin. The t-butyl cations formed in the hydrolysis of the ester can produce byproducts by reattaching to nucleophilic residues in the peptide, so nucleophilic scavengers such as thiophenol and anisole should be added to the cleavage mixture when Fmoc-Glu(OtBu)-OH are utilized.
"Fmoc-L-Gly-OH is an Fmoc-L-Amino acid for use in peptide synthesis. Fmoc-Gly-OH is the simplest Fmoc-amino acid, having no side chains and no chiral center. Because it is not chiral, Fmoc-Gly-OH is prefered at the C-terminal of peptide fragments to be coupled in fragment condesation synthesis. Linkers of various lengths can be formed by coupling glycine residues together. Glycine residues have only weak alpha helix and beta sheet forming properties, but with proline are strong turn inducers."
