1,3-diisopropylcarbodiimide is a carbodiimide compound having an isopropyl substituent on both nitrogen atoms. It has a role as a peptide coupling reagent. Often used widely in organic chemistry for the synthesis of amides, peptides, esters and various heterocycles. As a liquid, it is easier to handle than the commonly used N, N′-dicyclohexylcarbodiimide, a waxy solid.