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Fmoc-Asp(OtBu)-OH is the standard Fmoc-protected derivative of aspartic acid used in peptide synthesis. The t-butyl ester of the side chain is readily hydrolyzed in the same conditions used to cleave peptides from Wang resin or Rink amide resin. The t-butyl cations formed in the hydrolysis of the esters can produce byproducts by reattaching to nucleophilic residues in the peptide, so nucleophilic scavengers such as thiophenol and anisole should be added to the cleavage mixture when Fmoc-Asp(OtBu)-OH is utilized.
The side chain protecting group Mpe in Fmoc-Asp(OMpe)-OH is a more bulky group than the standard tert-Butyl (tBu) group, which significantly helps suppressing the notorious side reaction of aspartimide formation, and thus improve the purity of the crude peptide and facility the time- and cost-intensive purification as well.